Therefore the term “Fragile X Spectrum Disorder” (FXSD) should be used to include the wide range of overlapping phenotypes observed in affected individuals with FMR1 mutations. Some premutation carriers can have a deficit of FMRP and some unmethylated full mutation individuals can have elevated FMR1 mRNA that is considered a premutation problem. The premutation can also cause developmental problems including ASD and ADHD especially in boys and psychopathology including anxiety and depression in children and adults. FMR1 mutations account for a variety of phenotypes including the most common monogenetic cause of inherited intellectual disability (ID) and autism (FXS), the most common genetic form of ovarian failure, the fragile X-associated primary ovarian insufficiency (FXPOI, premutation) and fragile X-associated tremor/ataxia syndrome (FXTAS, premutation). Premutation carriers are common in the general population with approximately 1 in 130–250 females and 1 in 250–810 males, whereas the full mutation and Fragile X syndrome (FXS) occur in approximately 1 in 4000 to 1 in 7000. The normal allele of the FMR1 gene typically has 5 to 40 CGG repeats in the 5′ untranslated region abnormal alleles of dynamic mutations include the full mutation (> 200 CGG repeats), premutation (55–200 CGG repeats) and the gray zone mutation (45–54 CGG repeats). Publisher's Note: This book contains explicit sexual content, graphic language, and situations that some readers may find objectionable: Anal play/intercourse, male/male sexual practices, masturbation, violence.The fragile X mental retardation 1 gene ( FMR1), which codes for the fragile X mental retardation 1 protein (FMRP), is located at Xp27.3. But if they survive the investigation, they just might find love in retrograde. And as the detectives track down the killer, Robert helplessly waits for JD to recall the truth of their relationship and leave him yet again. Even JD's returning memory seems to conspire against Robert. Robert's best friend, police Captain Gabe Lara, seems to feel that Robert is better off without JD. Detective Bill Turner, who seems to have too personal an interest in JD, pegs Robert as the primary suspect in the shooting. It's the miracle Robert's been hoping for. He remembers their love, and seems determined to reconcile. As JD slowly regains his memories, he recalls everything except the circumstances of the murder, and the reasons why he left Robert. Robert rushes to JD's bedside to find him recovering from the gunshot wound but suffering from retrograde amnesia.

JD is in critical condition and the man who was with him is dead. Then one rainy night, he gets a call that his ex has been beaten and shot in a parking lot outside a gay dance club. “In the year since JD Ryan, Robert Lemos's life partner, packed his bags and moved out, Robert has been in a painful daze, anesthetizing himself with work.

Amor En Retrogrado by A.M. Riley